Chemomobilization with (R)-ICE (rituximab, ifosfamide, carboplatin, etoposide) compared to G-CSF and plerixafor (G+P) mobilization in lymphoid malignancies.

7033 Background: No studies have compared the efficacy and safety of chemomobilization with (R)-ICE against G+P mobilization in patients with lymphoid malignancies. Methods: We analyzed 126 consecutive patients with lymphoid malignancies undergoing chemomobilization with (R)-ICE (n = 63) or G + P (n = 63), in two different institutions. Results: Baseline characteristics are shown in Table 1. (R)-ICE mobilization provided a significantly higher total CD34+ cell yield (median 5.5 × 106 vs. 3.4 × 106 cells/kg, P < 0.001), day 1 CD34+ cell yield (2.4 × 106 vs. 1.7 × 106 cells/kg, P = 0.009) and CD34+ cell dose given at transplant (4.9 × 106 vs. 3.4 × 106 cells/kg, P < 0.001). The median number of apheresis sessions required was two in each group. Neutrophil engraftment was faster with (R)-ICE mobilization (median 10 days vs. 11 days, P < 0.001). Similarly platelet count recovery was faster with (R)-ICE (12 days vs. 16 days, P < 0.001). The transfusion of packed red blood cells was significantly higher in the ...