Oxidized LDL and other lipids as risk factors for cardiovascular disease in the patients with metabolic syndrome

Summary: We estimated relationship between lipids, LDL oxidation, antioxidant activity and CRP in diabetic patients with metabolic syndrom (MS), with and without coronary heart disease (CHD), in non diabetic patients with and without CHD and in obese patients, with and without diabetes. We didn’t find significant difference in lipids among diabetic MS patients. Patients from all subgroups have simillar level of oxLDL, but significant higher comparing with healthy control. MS diabetic patients have oxLDL in positive corelation with TC, LDL-C, non HDLC and apo B 100, as vell as with molar ratio LDL-C/HDL-C and TG/HDL-C (p<0.001). Among non diabetics, CHD patients had higher Lp(a), but oxLDL was simillar in both subgroups. In the nondiabetics we found correlation between oxLDL, TC, LDL-C and TG (p<0.01) and apo B 100 (p<0.001), but not with TG/HDL-C molar ratio. Obese patients from both groups had simillar lipids profile but, oxLDL was higher, not significant, in non diabetics. We didn’t find significant differences in antioxidative activity and CRP in both diabetics MS subgroups, and both obese subgroups. Nondiabetics with CHD have lower E-SOD and E-GPX activity and higher level of CRP than non CHD patients (p<0.05). MS diabetics and non diabetics didn't have significant correlation between levels of oxLDL and CRP, but CHD patients (with or without diabetes) had (p<0. 01).