Choriocarcinoma Mimicry of an Esophageal Carcinoma with Urinary Gonadotropic Activities

Clinical and postmortal findings of esophageal carcinoma in a 74-year-old woman with urinary activities of chorionic gonadotropin were described. The tumor was anaplastic carcinoma with prominent pleomorphism of large carcinoma cells showing choriocarcinoma mimicry. Abundant evidence of choriocarcinoma was further presented by pulmonary and hepatic metastases. Cystic glandular hyperplasia of the endometrium mild in degree and signs of activity in ovarian stromal cells were observed. The significance of choriocarcinoma mimicry as a morphological expression of ectopic producton of chorionic gonadotropin was discussed. Ana-plastic large cell carcinoma with choriocarcinoma mimicry is extremely rare in the esophagus but will be unexceptionally capable of gonadotropin-secretion. This is the first case report in the literature.