Effects of Rosuvastatin vs. Simvastatin on Carotid Atherosclerotic Plaque in Patients with Cerebral Infarction

OBJECTIVE:To investigate the effects of rosuvastatin and simvastatin on carotid atherosclerotic plaques in patientswith cerebral infarction. METHODS:100 cerebral infarction inpatients with carotid atherosclerotic plaques were collected from ourhospital,and they were randomized into treatment group and control group. On the basis of regular foundation treatment for cere-bral infarction,50 cases in treatment group were additionally given rosuvastatin orally,and other 50 cases in control group givensimvastatin orally. 6 months later,change of blood lipid was evaluated and carotid atherosclerosis plaques intima-media thickness(IMT) was observed by carotid ultrasound review. RESULTS:Total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) of 2 groups were decreased,and there was no statistical significance in TG of control group before and after treatment(P0.05) . The decrease of carotid plaques thickness in treatment group was more obvious than in control group,there was statisti-cal significance(P0.05) . CONCLUSION:Rosuvastatin is effective in the treatment of carotid atherosclerotic plaques in patientswith cerebral infarction,and it is worthy of spreading in the clinic.