UJI AKTIVITAS ANTI BAKTERI EKSTRAK METANOL DAUN BACCAUREA MACROCARPA TERHADAP ESCHERICHIA COLI DAN SALMONELLA TYPHI

Antibiotics are drugs that are used to inhibit bacteria production. The long-term use of antibiotics can cause resistance problems. As a consequent it is necessary to find the alternative antibiotics that are derived from plants. The alternative antibiotics are considered safer, relatively cheap and easy to obtain. One of the herbal plants used is Baccaurea macrocarpa. The objective of this study was to identify the secondary metabolites of B.macrocarpa, the effect of methanol extract from B.macrocarpa leaves on the growth of Escherichia coli and Salmonella typhi bacteria and to measure the optimal concentration of the sample to inhibit the growth of E.coli and S.typhi bacteria. The research has been conducted for 3 months at the Universitas Samudra laboratory. The method used was the well method with E.coli and S.typhi bacteria test. Each treatment of the methanol extract of B. macrocarpa leaves with a concentration of 20%, 30% and 40% (g/mL). Positive control was ciprofloxacin and negative control was sterile distilled water. The results obtained the concentration of 40% (g/mL) as the optimal concentration to inhibit the growth of E. coli and S.typhi bacteria with the resulting inhibition zone of 6.3 mm and 5 mm. The results of the study concluded that the B. Macrocarpa leaf extract could be developed as a basic ingredient for antibiotics.