Inhibitory Properties of Aniline, Aminophenol Compounds and their N-acetylated Derivatives on Carbonic Anhydrase

Carbonic anhydrases (CAs) are a group of metalloenzymes responsible for speeding up the conversion of carbon dioxide and water to a bicarbonate ion and a proton. CAs is divided into seven well-defined classes, namely, alpha, beta, gamma, delta, zeta, eta and theta. The alpha class of CAs is found in animal systems and is involved in various physiological and pathological processes. In some cases CA inhibition is required to treat certain disorders. Over the years metal complexing anions and sulfonamide compounds have been used extensively for this purpose. This paper investigated the potential inhibitory properties of aminophenol (AP) compounds and their acetylated derivatives against human cytosolic carbonic anhydrase (hCA) isozymes I and II.