Abstract 13768: Noninvasive Evaluation of the Impact of Left Ventricular Pressure Overload on Diastolic Function Using Speckle Tracking Echocardiography in Patients With Preserved Ejection Fraction

Introduction: Left ventricular (LV) pressure overload causes hypertrophy (LVH), which results in alterations in LV performance and may lead to heart failure (HF). The pathophysiology of HF with preserved ejection fraction (HFpEF) involves a predominant abnormality in diastolic function. We sought to evaluate the impact of pressure overload on the time constant of LV pressure decline (Tau) and myocardial stiffness in patients with preserved EF using speckle tracking echocardiography (STE). Results: We enrolled 420 subjects [58 controls (C) (age 67±11), 59 HTN without LVH (LVH -) (age 68±11), 70 HTN patients with LVH (LVH +) (age 70±11), 42 HFpEF patients (age 78±12), 154 hemodialysis (HD) patients with HTN (age 66±12) and 37 aortic stenosis (AS) patients (age 83±4)]. Pulmonary wedge pressure (PCWP) was estimeted (ePCWP) as 10.8 - 12.4 x log (left atrial active emptying function / minimum volume). Tau was estimated (eTau) as isovolumic relaxation time / (ln 0.9 x systolic BP - ln ePCWP) and validated by cat...