Graphene-based pipette tip solid-phase extraction with ultra high performance liquid chromatography and tandem mass spectrometry for the analysis of carbamate pesticide residues in fruit juice

Graphene-based pipette tip solid-phase extraction was combined with ultra high performance liquid chromatography-tandem mass spectrometry for the determination of carbamate pesticide residues in fruit juice samples. 4 mg of graphene was used as sorbent material to pack a 1000 μL pipette tip for the extraction of pirimicarb, propoxur, isoprocarb, fenobucarb and diethofencarb from 3 mL of fruit juice sample. The whole extraction process was finished in 12 min, and the volume of eluent used was only 1.5 mL. Under the optimized conditions, good linear relationship (R>0.999) and lower limits of detection (0.0022–0.033 ng⋅mL−1) were achieved. The recoveries at three spiked levels ranged from 80.90 to 124.60% with relative standard deviations less than 4.88%. Compared with commercially available sorbents including propylsulfonic acid silica, graphitized carbon black, and C18, graphene was superior in extraction efficiency. The proposed method is simple, rapid, sensitive, selective and solvent-saving. This article is protected by copyright. All rights reserved