Validation of S100B use in a cohort of Spanish patients with mild traumatic brain injury: a multicentre study

ABSTRACTIntroduction: The aim of this study was to validate the S100B protein as a diagnostic tool for ruling out the presence of intracranial lesion (IL) after mild traumatic brain injury (mTBI). Subjects with a Glasgow Coma Scale (GCS) score of 15 and at least one neurological symptom post-trauma were selected from a large Spanish cohort.Methods: A number of 260 patients with mTBI were enrolled. Blood samples were extracted within 6 h and CT scan performed within 24 h post-injury. Blood samples were also drawn from 18 healthy subjects.Results: CT scan revealed the presence of IL in 22 patients (8.5%). Patients with mTBI had higher S100B serum levels (p = 0.008) than the healthy subjects (p   65 (OR: 2.97; 95%CI: 1.04–8.44; p = 0.041) and S100B level >0.10 µg/L (OR: 7.93; 95%CI: 1....