EFFICACY STUDY OF ZINC CHLORIDE AND DIMINAZENE ACETURATE ON Trypanosoma brucei INOCULATED RATS

The effect of Zinc  Chloride  (ZnCl ) and Diminazene aceturate  in  experimental  Trypanosoma brucei    2   infected rats was investigated. Six groups (A-F) consisting of five rats each were used. A and F were    negative and positive controls, while B, C, D, and E were treated groups, respectively. The infection    6    was achieved by inoculating (1x10 ) of the parasite and rapid matching method was used to estimate    the parasitaemia in the host. Parasitaemia was monitored for 30 days using wet mount method. The    inoculated treated groups progressively showed parasitaemia five days post inoculation that caused    significant decrease (p<0.05) in packed cell volume (PCV) and white blood cell (WBC) count. After    treatment with ZnCl2  and Diminazene Aceturate (Group D), there was a remarkable improvement to-    wards the normal (Group A). This study shows that supplemental ZnCl2  could be used to alleviate the    severity of the infection in Trypanosomosis.