Ymf 1029A-E, Preussomerin Analogues from the Fresh-Water-Derived Fungus YMF 1.01029
2008
Five new preussomerin analogues, ymf 1029A (1), B (2), C (3), D (4), and E (5), were isolated from the liquid cultures of an unidentified freshwater fungus YMF 1.01029, along with four known compounds, preussomerin C (6), preussomerin D (7), (4RS)- 4,8-dihydroxy-3,4-dihydronaphthalen-1 (2H) -one (8), and 4,6,8-trihydroxy-3,4-dihydronaphthalen-1 (2H)-one (9). The structures of new metabolites were determined by analysis of NMR and MS data and by analogy with the data for the known bis-spirobisnaphthalene preussomerins. In vitro immersion experiments showed that these metabolites displayed weak nematicidal activity against Bursaphelenchus xylophilus, while compound 7 was the most potent. This is the first report of these compounds, which antagonize the Bursaphelenchus xylophilus nematode.
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