3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors
2001
Abstract Design, synthesis and structure–activity relationship of a class of 3-aryl-4-aryloyl-1-(1 H -imidazol-5-yl)methylpyrroles as farnesyltransferase inhibitors are described. Compound 7 inhibits farnesyltransferase with an IC 50 value of 4.6 nM.
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