Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4/NF-кB and PI3K/AKT signalling pathways

Zhaohui Wang,Zhi Chen,Bingsheng Li,Bo Zhang,Yongchao Du,Yuhang Liu,Yao He,Xiang Chen

Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4/NF-кB and PI3K/AKT signalling pathways

2020

Zhaohui Wang
Zhi Chen
Bingsheng Li
Bo Zhang
Yongchao Du
Yuhang Liu
Yao He
Xiang Chen

Renal interstitial fibrosis (RIF) is characterized by the accumulation of inflammatory cytokines and epithelial-mesenchymal transition (EMT). Curcumin exerts antifibrogenic, anti-inflammatory and a...

Keywords:

Renal interstitial fibrosis
Curcumin
Obstructive Nephropathy
Cancer research
Inflammation
Epithelial–mesenchymal transition
Medicine
PI3K/AKT/mTOR pathway
TLR4
Proinflammatory cytokine

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