DEGRADATION STUDY OF FIVE DIFFERENT B RANDS OF CIPROFLOXACIN USING UV VISIBLE SPECTROPHOTOMETER AND THEIR COMPARATIVE STUDY

Degradation studies help to anticipate the future stability issue the drug product may undergo, and provide useful information for both formulation and stability. We explored the degree of degradati on in five dif ferent brands of C iprofloxacin tablet, with the purpose to determine the most stable brand out of the five. 500 ppm and 250 ppm samples of each brand were prepared to observ e the effect of time, acid (0.1N HCl) and base (0.1 N NaOH). Their absorbance was re corded using a Shimadzu UV - Visible spectrophotometer at 2 71.4 nm. The results suggest tha t out of the five brands, c yrocin possessed the highest stability and degraded the least.