Coombs'-Negative Autoimmune Hemolytic Anemia in a Patient With Small Lymphocytic Lymphoma Involving the Bone Marrow

1. What are some possible causes of hemolytic anemia and into which 2 broad categories can they be divided? 2. What is the only hemolytic anemia caused by an acquired intrinsic defect in the RBC cell membrane? 3. What is Coombs’ testing? 4. What are some of the possible etiologies of autoimmune hemolytic anemia? 5. What is an appropriate workup for a Coombs’-negative hemolytic anemia that is suspected to be autoimmune?