Mediators of immune regulation and immunotherapy : proceedings of the international symposium, Mediators of immune regulation and immunotherapy, held June 13-15, 1985, at the University of Western Ontario, London, Ontario, Canada

List of participants. Acknowledgments. SESSION I. T-CELL ANTIGEN PRESENTING CELL REGULATORY MOLECULES (Chairman: H. Wigzell). Regulation of lymphokine expression (V. Paetkau, J. Shaw, J. Ng, J.F. Elliott, K. Meerovitch, P.J. Barr, and R.C. Bleackley). Studies on the mechanism of processing and preservation of insulin by antigen presenting cells (T.L. Delovitch, M.L. Phillips, P. Naquet, C.C. Yip, J. Lin, and M. Skinner). Steps in the process of T lymphocyte activation (C.A. Janeway Jr., P.J. Conrad, J.B. Horowitz, M.E. Katz, J. Kaye, K.M. Saizawa, L. Smith, and J.P. Tite). SESSION II. IMMUNOREGULATORY CELLS AND MOLECULES (Chairman: C. Janeway). Regulation of normal and autoimmune responses by bone marrow derived mediators (M.J. Atkinson, F. Mortari, D.C. Saffran, G.A. McCain, and S.K. Singhal). Regulatory T-cell subsets (C.W. Pierce, J.A. Kapp, P.E. Jensen, J.P. Lake, M.T. Lopez, R.Y.M. Poon, and C.M. Sorensen). Antigen specific suppressor factors: current perspectives (D.R. Webb, J.A. Kapp, K. Krupen, C.W. Pierce, C.M. Sorensen, and C.W. Turck). T-cell factors involved in the regulation of IgE synthesis (K. Ishizaka). Information trafficking by regulatory lymphocytes: some thoughts (P.M. Flood). Genetic control of immunoregulatory molecules with anti-suppressor activity (F. Paraskevas, S.T. Lee, and J. Maeba). SESSION III. STEM CELL DIFFERENTIATION AND REGULATORY MOLECULES (Chairman: R. Phillips). Stem cell self-renewal and differentiation (T.M. Dexter, C.M. Heyworth, and E. Spooncer). Regulation of human lymphopoiesis: activity on T-cell colony growth by factors derived from normal and leukemic marrow (M.A. Bains, F. Mortari, S. Nichols, and S.K. Singhal). SESSION IV. B-CELL DIFFERENTIATION AND PROMOTING MOLECULES (Chairman: D. Osmond). Regulation of bone marrow lymphocyte production (D.G. Osmond and C. Pietrangeli). Mediators in proliferation and maturation of B-cell precursors (P.W. Kincade, V. Vetvicka, K.S. Landreth, P.L. Witte, and H. Jyonouchi). Lymphokine regulation of polyclonal and antigen specific B cell responses (M. Howard, P. Stein, and P. Dubois). Lymphokines affecting B cell maturation (C.L. Sidman, K.E. Sahr, and D.I. Sherris). Immunoglobulin isotype switching in humans (P.D. Burrows, H. Kubagawa, G.V. Borzillo, and M.D. Cooper). Anti-Fc antibodies and B cell activation (N.R. StC. Sinclair and A. Panoskaltsis). SESSION V. MOLECULAR MANIPULATION AND IMMUNOTHERAPY (Chairmen: T. Waldmann and S. Strober). Selective suppression of murine lymphocyte function by daunomycin conjugated via an acid sensitive spacer to target specific carriers (U. Diner, E. Diener, A. Sinha, S. Xie, and R. Vergidis). Use of monoclonal antibody to the interleukin-2 receptor in therapy of patients with adult T-cell leukemia (T.A. Waldmann). The use of nonionic, water soluble polymers for the synthesis of tolerogenic conjugates of antigens (A.H. Sehon and G.M. Lang).