Atorvastatin calcium enteric-coated pellet and preparation method thereof

The invention belongs to the field of pharmaceutical preparations and discloses an atorvastatin calcium enteric-coated pellet and a preparation method thereof. The enteric-coated pellet is prepared through the following preparation method which comprises the following steps of: (a) preparing a spheroid or spheroid-like blank pellet core by using an extrusion-spheronization method; (b) carrying out spray coating on the blank pellet core by using an atorvastatin-calcium-containing water-soluble coating solution to obtain a drug-containing pellet core, or, further coating an isolating substance on the drug-containing pellet core; and (c) carrying out spray coating on the drug-containing pellet core coated or not coated by the isolating substance by using an enteric polymer coating solution so as to obtain the atorvastatin calcium enteric-coated pellet. According to the preparation method of the atorvastatin calcium enteric-coated pellet, the blank pellet core with low friability, higher yield, smaller grain size and bright and clean surface can be obtained, and thus, the blank pellet core is convenient to further process. According to the atorvastatin calcium enteric-coated pellet and the preparation method thereof, the atorvastatin calcium enteric-coated pellet is prepared by coating active ingredients and a functional enteric coating on the blank pellet core and has the characteristic of controllable and stable in-vitro quality.