Research advances in the relationship between PARP-1 and its inhibitors and the development, progression, and radiosensitivity of tumors

Poly (ADP-ribose) polymerase-1(PARP-1), a ubiquitous and abundant nuclear protein composed of amino-acid residues, plays an important role in the process of DNA damage repair. In recent years, some studies have confirmed that PARP-1 is closely related to the development and progression of tumors, and may influence the tumor radiosensitivity. This article summarizes the relationship of PARP-1 and its inhibitors and the development, progression, and radiosensitivity of tumors. Key words: Poly ADP-ribose polymerase-1; Inhibitor; Tumor; Radiosensitivity