Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
2009
The Plk1 kinase is a major regulator of mitosis that is often overexpressed in human cancers. Studies on phosphopeptide inhibitors specific to the polo-box domain of Plk1 reveal the determinants for specificity and may provide insight into the development of new therapeutics targeting protein-protein interactions.
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