Azaperone and the hepatic microsomes: effects on cytochrome P-450 concentration and on NADPH-cytochrome c-reductase activity.

: Twelve male mice weighing about 16 g were given 4 mg/kg azaperone subcutaneously in 0.5 ml of water. Twelve similar mice which were given 0.5 ml of water subcutaneously at the same time were kept as controls. After 7 days all the mice were sacrificed and the total protein content, the microsomal protein content, the microsomal cytochrome P-450 concentration and the microsomal NADPH-cytochrome c-reductase activity of the livers was determined. In the azaperone-treated group the mean microsomal cytochrome P-450 concentration of the livers was significantly increased but the mean microsomal NADPH-cytochrome c-reductase activity of the livers was significantly decreased as compared to the controls.