Mechanism of inhibition of tumor metastasis by breast cancer metastasis suppressor 1

Breast cancer metastasis suppressor 1(BRMS1)can suppress the tumor cells metastasis. and significantly reduces the metastasis without affecting tumor growth. The relevant mechanism(s)may be related to intercellular communication, phosphoinositide signal transduction and interaction with NF-KB, and so on. Therefore, exploring the mechanisms of inhibition of tumor metastasis might be helpful for use of BRMS1 as tumor gene therapy. Key words: Neoplam metastasis; BRMS1