Spinal protein kinase C/extracellular signal–regulated kinase signal pathway mediates hyperalgesia priming
2018
AbstractChronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal nociceptive thresholds of the animal are normal, but, in response to another hyperalgesic stimulus, the animal develops enhanced and prolonged hyperalges
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