Asymmetric synthesis and absolute stereochemistry of 4,4-bis-(trifluoromethyl)imidazoline based ACAT inhibitors

Hui-Yin Li,I. Delucca,Spencer Drummond,George A. Boswell

Asymmetric synthesis and absolute stereochemistry of 4,4-bis-(trifluoromethyl)imidazoline based ACAT inhibitors

1997

Hui-Yin Li
I. Delucca
Spencer Drummond
George A. Boswell

Abstract An asymmetric synthesis of 1 , a potent orally active ACAT inhibitor, is reported. The absolute configuration of 1 has been determined by exciton CD spectra and X-ray crystal structure analysis.

Keywords:

Absolute configuration
Imidazoline receptor
Enantioselective synthesis
Trifluoromethyl
Photochemistry
Exciton
Organic chemistry
Chemistry
Crystal structure
Stereoselectivity
Stereochemistry
Combinatorial chemistry

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