Iloprost prevents doxorubicin mediated human cardiac progenitor cell depletion

The most plausible explanation for the link between CD and cardiomyopathy is that both conditions might be mediated through inflammation and autoimmune mechanisms [5]. Nutritional deficiencies might be a further explanation for the association between cardiomyopathy and CD. Folate deficiency, like in our patient, was found in 20% of adults with newly diagnosed CD [9]. In animal experiments, folate deficiency has been shown to cause myocardial thickening and cardiomyopathy [10]. If folate deficiency plays a role in the development of LVHT is unknown. From our findings we conclude that LVHT may be associated with CD, folate deficiency and stroke. If this association is a pure coincidence or due to a common etiologic factor remains unknown. Since CD is frequently overlooked and is treatable by gluten-free diet, efforts should be made to discover this disease in patients with cardiomyopathies including LVHT. Patients with LVHT and chronic gastrointestinal symptoms should be investigated for CD. The role of folate deficiency in the etiology of cardiomyopathies including LVHT needs to be investigated. The authors report no relationships that could be construed as a conflict of interest. References