Solid-Phase Synthesis of Hydrogen-Bond Surrogate-Derived α-Helices
2005
This report describes the solid-phase synthesis of hydrogen-bond surrogate-derived artificial α-helices by a ring-closing metathesis reaction. From a series of metathesis catalysts evaluated for the synthesis of these helices, the Hoveyda−Grubbs catalyst was found to afford high yields of the macrocycle irrespective of the peptide sequence.
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