Synthesis and antitumor evaluation of benzoylphenylurea analogs.
2004
Abstract Novel series of benzoylphenylurea analogs 7 – 10 were prepared and evaluated for in vitro cytotoxic activity against a panel of eight different human cancer cell lines. A very interesting inhibition profile against BxPC3, Mia-Paca, and Hep2 cells with compound 10 has been observed. Compounds 8 and 9 showed the significant cytotoxicity in Hep2 cells. All cell lines were resistant to compound 7 .
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