Design, synthesis, and conformational analysis of a novel series of HIV protease inhibitors
1998
Abstract A combination of structure-based design and both solution, and solid-phase synthesis were utilized to derive a potent (nM) series of HIV-1 protease inhibitors bearing a structurally novel backbone. Detailed structural analysis of several inhibitors prepared in this series has suggested that rigidification of the P 1 /P 2 region of this class of molecules may result in compounds with improved potency.
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