Chapter 33 – Error and t Images Depend on ANOVA Design and Anatomical Standardization in PET Activation Analysis 1

Publisher Summary In a positron emission tomography activation analysis with task replications within subject, a number of analysis of variance (ANOVA) designs are applicable with different definitions of t and error. The characteristics of t (and z) maps and error images and their dependance on the ANOVA design, and on the anatomical standardization method are investigated in this chapter. Six subjects underwent measurement of regional cerebral blood flow with (15O) water under resting and while thinking of verbs associated with auditorily presented nouns, three times for each. The foci localization in the z images depended both on the anatomical standardization method and on the ANOVA design, and the variation ranged from 1 to 3 cm. SPM tended to present a higher peak z than LIN and HBA. The z images of 2W and 2WI looked alike, but 2WI-RF and 3W each presented a different z map within the activated area.