Studies on the effectiveness of H1-+H2-antagonist combinations in preventing life-threatening anaphylactoid reactions in anaesthesia and surgery: Problems with selecting the animal model from clinical data and with “equi-effective” doses

Animal models are necessary for studies on the effectiveness of histamine H1- + H2-receptor antagonists in preventing life-threatening anaphylactoid reactions in anaesthesia and surgery. Clinical data were presented here for the first time which showed a clear correlation between the severe haemodynamic changes (shock and death) and plasma histamine levels.