Methemoglobinemia as a biomarker of dapsone-induced mania severity

Abstract Background The underlying mechanism involved in dapsone-induced mania remains unknown. Methods We report the case of a 54-year-old man with a dapsone-induced mania. Results The maximum of manic symptoms was correlated with the maximum of methemoglobinemia and mania decreased concomitantly with the methemoglobinemia level. Limitations This is a single case. Conclusions This case shows that dapsone-induced mania severity is correlated with methemoglobinemia level, leading for the first time to the hypothesis of a physiopathological mechanism by which dapsone could induce mania.