First Total Synthesis of BE-12406 A.

Abstract A concise total synthesis of BE-12406 A ( 3a ) was achieved. The key step was the selective O -glycosylation of naphthol 4 with l -rhamnopyranosyl fluoride 5 , employing Cp 2 HfCl 2 -AgClO 4 in fluorobenzene at −20°C in the presence of a hindered base 9 , affording O -glycoside 8 in good yield.