Investigation of the mechanism of action of a potent pateamine A analog, des-methyl, des-amino pateamine A (DMDAPatA)

Sai Shilpa Kommaraju,Julieta Aulicino,Shruthi Gobbooru,Jing Li,Mingzhao Zhu,Daniel Romo,Woon-Kai Low

Investigation of the mechanism of action of a potent pateamine A analog, des-methyl, des-amino pateamine A (DMDAPatA)

2020

Sai Shilpa Kommaraju
Julieta Aulicino
Shruthi Gobbooru
Jing Li
Mingzhao Zhu
Daniel Romo
Woon-Kai Low

The natural product pateamineA (PatA) is a highly potent antiproliferative agent. PatA and the simplified analog desmethyl, desamino pateamineA (DMDAPatA) have exhibited cytotoxicity selective for ...

Keywords:

Cytotoxicity
Mechanism of action
Desmethyl
Natural product
Biochemistry
Biology

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