Sequential C-O Decarboxylative Vinylation/C-H Arylation of Cyclic Oxalates via Nickel-Catalyzed Multicomponent Radical Cascade

A selective, sequential C-O decarboxylative vinylation/ C-H arylation cyclic alcohol derivatives enabled by visible-light photoredox/nickel dual catalysis is described. This protocol utilizes a multicomponent radical cascade process, i.e. decarboxylative vinylation/1,5-HAT/aryl cross-coupling, to achieve the efficient, site-selective dual-functionalization of saturated cyclic hydrocarbons in one single operation. This synergistic protocol provides straightforward access to sp3-enriched scaffolds and an alternative retrosynthetic disconnection to diversely functionalized saturated ring systems from the simple starting materials.