Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery "The ana lysis of all the data available in the literature suggests the adequacy of the biomaterial pullulan for drug-delivery strategies. Particularly, although counting on a reduced number of works, pullulan-based nanoparticles reveal potential regarding transmucosal protein delivery."

Current advances in the field of drug delivery are aimed at finding adequate strategies for the administration of different drugs. Transmucosal delivery is the first-line option for the systemic delivery of many drugs, including proteins, a group of molecules with recognized therapeutic potential and wide range of applications (drug and genetic therapy, immunization, among others). This strategy, however, demands developing adequate carriers, as proteins are very sensitive molecules, easily undergoing degradation in physiological media, mainly due to pH and enzymatic occurrences. Polymeric nanopar