Flavanone and Flavonol Glycosides from the Leaves of Thevetia peruviana and Their HIV-1 Reverse Transcriptase and HIV-1 Integrase Inhibitory Activities

Two new flavanone glucosides, (2R)- and (2S)-5-O-β-D-glucopyranosyl-7,4′-dihydroxy-3′,5′-dimethoxyflavanone[pervianoside I (3), peruvianoside II (4)] and a new flavonol glycoside, quercetin 3-O-{β-D-glucopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→6)]-β-D-galactopyranoside} (peruvianoside III, 13) were isolated from the leaves of Thevetia peruviana SCHUM., together with nine known flavonol glycosides and two known iridoid glucosides. The structures of all compounds were determined on the basis of chemical and spectroscopic methods. Their inhibitory effects against HIV-1 reverse transcriptase and HIV-1 integrase were also investigated.