Optimal patient selection for electron intraoperative radiotherapy (IORT) as sole treatment for breast cancer.

1059Background: Several phase III trials of breast IORT have recently been published with findings that have generated significant controversy and discussion. As different techniques were used in these trials in a broad range of patients, it is unclear if the results obtained were due to differences in technique, type of radiation or patient selection. The goal of the current study was to review findings from studies using only electron IORT in appropriately selected patients considered suitable for APBI. Methods: We performed a literature search addressing the use of electron IORT as the sole radiation treatment for early stage breast cancer. Publications that delivered IORT prior to tumor excision, and those that did not deliver the prescription dose as deeply as the chest wall, were excluded. The ASTRO and ESTRO Consensus guidelines were used to select patients from these studies based upon society derived criteria for the application of APBI. ESTRO Good category differs from ASTRO Suitable in that it ...