Serial Iron, Zinc and Copper Status in Adults with Pulmonary Tuberculosis in the Country of Georgia

Objective: To determine serial dietary intake and serum concentrations of immune-related micronutrients in patients with TB disease. Methods: Estimated mean daily intake of iron (Fe), zinc (Zn), and copper (Cu) was determined in 192 adults with pulmonary TB within 7 days of diagnosis and at 16 weeks using a validated instrument and NDS-R. Serum levels of Fe, Zn and Cu were determined by inductively coupled argon plasma spectrometry at baseline and week 16. Results: Mean subject age was 34 y and 64% were male. Serum Fe levels were below normal in 25% at baseline (24±20 umol/L), and rose significantly by week 16 [to 26±15 umol/L (P< 0.01)]. Mean dietary Fe intake at baseline and week 16 was adequate. Serum Zn levels were below normal in 35% at baseline (11.6±2.8 umol/L) and 26% at week 16 (12.2±3.2 umol/L). Mean dietary Zn intake at baseline was 11.7±5.0 mg/day (121% of RDA)] and decreased at wk 16 (to 10±3.5 mg/day;P=0.03). Serum Cu levels were normal at baseline (26.5±0.6 umol/L) and fell significantly by...