RNAi inhibition of expression of alpha-ENaC

A composition comprising an RNAi agent comprising a coding strand and a non-coding, where chain: a. the coding strand comprises at least 19 contiguous nucleotides from the coding strand of ND8357 (SEQ ID NO: 145), and the antisense strand comprises at least 19 contiguous nucleotides from the antisense strand of ND8357 (SEQ ID NO: 146); or b. the coding strand comprises at least 19 contiguous nucleotides from the coding strand of ND8573 (SEQ ID NO: 449), and the antisense strand comprises at least 19 contiguous nucleotides from the antisense strand of ND8573 (SEQ ID NO: 450); or c. the coding strand comprises at least 19 contiguous nucleotides from the coding strand of ND8313 10 (SEQ ID NO: 57), and the antisense strand comprises at least 19 contiguous nucleotides from the antisense strand of ND8313 (SEQ ID NO : 58).