Synthesis of 1-benzoyl-3-alkylthioureas by transamidation under microwave in dry media

Abstract 1-Benzoyl-3,3-diethylthiourea was transamidated with several amines to the corresponding 1-benzoyl-3-alkylthioureas in open vessels under microwave irradiation using a domestic oven. The syntheses were performed in solvent-free conditions on potassium fluoride impregnated alumina. Yields were dramatically improved in comparison with classical heating under the same conditions.