Protective Activity of Anti-Exotoxin A Monoclonal Antibody against Mice Infected with Toxin-Producing Pseudomonas aeruginosa

The neutralizing and protective effect of murine monoclonal antibody (MAb) 3C7 (IgGl) against Pseudomonas aeruginosa exotoxin A was examined in an experimental mouse model of infection with exotoxin A-producing strains. Treatment with MAb 3C7 blocked the reduction of functional elongation factor 2 (EF-2) in the liver of mice but could not clear the bacteria. Administration of gentamicin caused bacteria to be cleared but did not block reductionof hepatic EF-2 level