Structural study of highly halogenated dihydropyridine derivatives as potential calcium channel modulators

Two dihydropyridines endowed with fluorine atoms (3) and fluorine and chlorine atoms (4) have been synthesized and structurally characterized by experimental X-ray analyses and theoretical calculations at the semiempirical (AMI) and ab initio (HF/6–31G*) levels. The results show that these compounds meet the required criteria to act as potential calcium channel modulators.