Evaluation of airway measurements in phantom parenchyma and soft tissue regions
2008
The purpose of this work was to develop a 3D airway measurement technique that can be initialized at a single point
(either automatically or user defined) and to evaluate the measurement accuracy with varying imaging parameters as
well as in synthetic parenchyma and soft tissue regions. This approach may have advantages over existing methods
that require segmentation of the entire airway branch. METHODS: Rays are cast spherically from the initial
measurement point and a range image is created of the distance to the edge of the airway lumen. The trajectory of
the airway is estimated from the range image, and can be used to re-construct a 2D slice perpendicular to the airway
for cross-sectional measurements. The evaluation phantom consisted of 5 tubes (3.18 to 19.05 mm in diameter and
1.59 to 3.18 mm in wall thickness) embedded in synthetic lung parenchyma and soft tissue. Images were acquired at
10 and 100 mAs at three tube orientations (0°, 45°, 90°) and were reconstructed at 0.6 and 1.5 mm slice thicknesses
with both smooth and standard reconstruction kernels. RESULTS: The overall diameter and wall thickness accuracy
was 0.43 ± 0.19 mm and 0.28 ± 0.15 mm respectively in parenchyma regions and 0.46 ± 0.16 mm and 0.49 ± 0.40
mm respectively in the soft tissue regions. The overall accuracy of the trajectory estimate was 0.64 ± 0.51°. The
proposed technique may allow a potentially larger number of airways to be measured for research and clinical
analysis than with current methods.
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