Astımlı çocuklarda serum miyeloperoksidaz düzeyleri

Aim: In this study, we assessed the serum levels enzyme myeloperoxidase (MPO), which is a marker for neutrophile activation and shows bactericidal effect, in children having bronchial asthma. We investigated the effect of neutrophiles and MPO on asthma and also its relationship between the severity of the disease and attacks. Material and method: In this study, 3-14 years old 115 patients having bronchial asthma, which has episodic coughing, dispnea and noisy breathing, were included. Well-child outpatient clinic control group was formed by 30 healthy children. Serum MPO levels were measured by using enzyme immunoassay (ELISA) method. Results: The mean age of children having asthma was 7. 28 ± 3.2 years old in this study. There was a statistically significant difference between children having asthma and control group in serum MPO levels (p 0.05). During asthma attack, serum MPO levels and the percentage of neutrophiles were significantly increased (p<0.001), but serum IgE levels and the percentage of eosinophiles didn’t change. Conclusion: We determined that asthma can be an inflammation with neutrophilia, but without a usual atopy, allergy and eosinophilia, during disease attacks