P11-21. Induction of persistent mucosal humoral and cellular responses following immunization of mice with HIV-1 envelope protein in inulin-derived adjuvants

Background Since HIV transmits primarily via mucosal route during sexual transmission; an ideal HIV-1 vaccine should induce both systemic and mucosal humoral and cellular responses. Although HIV envelope formulated with QS21 or Alum elicits strong systemic antibody responses, mucosal antibody and T-cell responses are generally weak. Herein we examined the systemic and mucosal immune responses elicited following a DNA prime/protein boost HIV vaccine formulated with inulin-derived (Advax) adjuvants. Such adjuvants have been shown to be less reactogenic and can induce immune responses in systemic and mucosal compartments.