Self-controlled case series methodology

The self-controlled case series method is an epidemiological study design in which individuals act as their own control. The method offers advantages but has several limitations. This article outlines the self-controlled case series method and reviews methodological developments that address some of these limitations. Expected final online publication date for the Annual Review of Statistics and Its Application Volume 6 is March 7, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.