Effect of parenteral acetazolamide on intestinal absorption of salt and water in man.

SummaryAcetazolamide was administered intravenously during jejunal perfusion of isotonic saline in six subjects. Bicarbonate was present in very low concentration intraluminally and there was net bicarbonate secretion during control and acetazolamide perfusions. Acetazolamide significantly inhibited sodium chloride, and water absorption. As this occurred in the absence of an effect on net bicarbonate secretion, it may have been due to an action other than carbonic anhydrase inhibition.This research was supported by the National Foundation for Ileitis and Colitis, Inc., and by Grant RR-71 to the Clinical Research Center of The Mount Sinai Hospital. Lederle Laboratories kindly donated the acetazolamide.