Cytotoxic‐Antineoplastic Derivatives of Prenyl‐1,2‐naphthohydroquinone
2008
Several new prenyl-1,2-naphthohydroquinone derivatives have been prepared by chemical modifications of Diels-Alder products which were obtained from cycloaddition of α-myrcene to 1,2-benzoquinone and then evaluated in vitro for their cytotoxic activity against A-549 lung carcinoma, HT-29 colon carcinoma, and MB-231 breast adeno-carcinoma culture cells. Most of them exhibited GI 50 values in the μM-concentration level.
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