PP10.9 – 2483: Neurodevelopmental outcome of infants with neonatal seizures

Objective Prospective study was performed on a cohort of 100 patients: term and preterm newborns, who had clinically manifested seizures during the neonatal period. Methods Initial assessment was performed during their hospitalisation, while furder follow-up was done through regular visits to outpatient facilities of Deparment of Child Neurology. Patients were divided into two groups – preterm and term newborns (67/33). During early and late neonatal period, 23 children died (12 terms/11 preterms). Use of medications and drugs during pregnancy (38%), underlaying disease in mothers (22%), type of labour (vaginaly 61%), intrauterine growth restriction (28%), necessity for resustitation mesures (54%), perinatal aspyxia (52%) and mechanical ventilation (54%) were considered as risk factor. Neurodevelopmental assessment was performed at the age of one year with Alberta Infant Motor scale (AIMS) and Developmental scale. Results According to AIMS 68.83% patients had scores below 10 th percentile which corresponded to motoric developmental delay. According to Developmental scale, 62.33% of children showed developmental discordance with the results expected for chronological age. 28.57% of patients with diagnosis of epilepsy at the age of one year had also low scores at AIMS ( Conclusion Neonatal seizures have strong prediction for short and long term morbidity and mortality.