Specific binding proteins for growth factors, insulin-like and uses thereof

Specific binding protein isolated fully human that preferentially binds to factor decrease insulin-II (IGF-II) with cross-reactive growth factor insulin-I (IGF-I) and neutralizes the activity of IGF-I and IGF-II, comprising said binding protein, or fragment deunion thereof: one complementarity determining region of heavy chain 1 (CDR1) having the sequence deaminoacidos of "Ser Tyr Asp Ile Asn" (SEQ ID NO: 33); one complementarity determining region of heavy chain 2 (CDR2) having the deaminoacidos sequence "Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln Gly" (SEQ ID NO: 34), a complementarity determining region heavy chain 3 (CDR3) having the deaminoacidos sequence "Asp Pro Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val" (SEQ ID NO: 35), a complementarity determining region light chain 1 (CDR1) having the sequence deaminoacidos of "Ser Ser Ser Ser Gly As n Ile Glu Asn Asn His Val Ser "(SEQ ID NO: 36), a complementarity determining region light chain 2 (CDR2) having the deaminoacidos sequence" Asp Asn Asn Lys Arg Pro Ser "(SEQ ID NO: 37 ); yuna complementarity determining region light chain 3 (CDR3) having the sequence deaminoacidos "Glu Thr Trp Asp Thr Ser Leu Ser Ala Gly Arg Val" (SEQ ID NO: 38).