Cost-minimization Analysis of 2 Schemes for Pediatric Acute Suppurative Tonsillitis

OBJECTIVE: To evaluate the curative effects and pharmacoeconics of 2 different dosage schemes for pediatric acute suppurative tonsillitis.METHODS: A prospective randomized controlled trial was performed,pediatric acute suppurative tonsillitis patients were treated with 2 dosage schemes,scheme A were ceftazidine by continuous intravenous drip and scheme B were ceftazidine and cefixime by sequential therapy,the cost-minimization analysis was performed on 2 schemes.RESULTS: There were no significant differences between 2 schemes in curative effects,bacteria clearance rates and incidences of ADRs(P0.05),whereas the expenditures in antibiotics and the total treatment cost in scheme B were significantly lower than in scheme A(P0.001).CONCLUSIONS: Sequential use of ceftazidine and cefixime for pediatric acute suppurative tonsillitis is not only safe and effective,but also more economical and reasonable.